AUTOCRINE GROWTH BY 2 CYTOKINES, INTERLEUKIN-6 AND TUMOR NECROSIS FACTOR-ALPHA, IN THE MYELOMA CELL-LINE KHM-1A

被引：32

作者：

HATA, H ^{[1
]}

MATSUZAKI, H ^{[1
]}

TAKATSUKI, K ^{[1
]}

机构：

[1] KUMAMOTO UNIV,SCH MED,DEPT INTERNAL MED 2,HONJO 1-1-1,KUMAMOTO 860,JAPAN

来源：

ACTA HAEMATOLOGICA | 1990年 / 83卷 / 03期

关键词：

Autocrine; Interleukin-6; Myeloma; Tumor necrosis factor;

D O I：

10.1159/000205189

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effects of tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) on the cell growth of the myeloma cell line KHM-1A were studied. TNF-α strongly induced KHM-1A proliferation, while IL-6 weakly enhanced growth only at low cell densities. When TNF-α was combined with IL-6, TNF-α-induced growth enhancement was reduced. According to Northern blotting analysis, the m-RNA of both TNF-α and IL-6 were detected in KHM-1A. Moreover, monoclonal antibody capable of neutralizing the cytotoxic activity of TNF-α inhibited the proliferation of this cell line. These findings suggest that this cell line operates under an autocrine growth mechanism with respect to these two cytokines, IL-6 and TNF-α

引用

页码：133 / 136

页数：4

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