BETA-ADRENERGIC BLOCKING AGENTS .4. VARIATION OF 2-NAPHTHYL GROUP OF PRONETHALOL [2-ISOPROPYLAMINO-1-(2-NAPHTHYL)ETHONOL]

被引：14
作者：
HOWE, R
MCLOUGHLIN, BJ
RAO, BS
SMITH, LH
CHODNEKAR, MS
机构：
[1] Imperial Chemical Industries Ltd., Pharmaceuticals Division, Macclesfield, Cheshire, Alderley Park
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1969年 / 12卷 / 03期
关键词：
D O I：
10.1021/jm00303a027
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In attempts to improve the potency of the adrenergic (β-receptor antagonist pronethalol [2-isopropylamino-1- (2-naphthyl)ethanol] the 2-naphthyl group has been replaced by, for example, 1-naphthyl, tetrahydro-2-naphthyl, 5-indanyl, and various tricarbocyclic groups. Analogs have also been made with substituents other than i-Pr on N. Structure-activity relationships are discussed. Several of the compounds described have the same level of potency as pronethalol. © 1969, American Chemical Society. All rights reserved.
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页码：452 / +
页数：1
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