Stimuli Responsive Poly(Vinyl Caprolactam) Gels for Biomedical Applications

被引：69

作者：

Rao, Kummara Madhusudana ^{[1
]}

Rao, Kummari Subba Venkata Krishna ^{[2
,3
]}

Ha, Chang-Sik ^{[1
]}

机构：

[1] Pusan Natl Univ, Dept Polymer Sci & Engn, Busan 609735, South Korea

[2] Yogi Vemana Univ, Dept Chem, Kadapa 516003, Andhra Pradesh, India

[3] Wayne State Univ, Dept Chem Engn & Mat Sci, Detroit, MI 48202 USA

来源：

GELS | 2016年 / 2卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

stimuli responsive; gels; poly(vinyl caprolactam); biomedical applications;

D O I：

10.3390/gels2010006

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Poly(vinyl caprolactam) (PNVCL) is one of the most important thermoresponsive polymers because it is similar to poly(N-isopropyl acrylamide). PNVCL precipitates from aqueous solutions in a physiological temperature range (32-34 degrees C). The use of PNVCL instead of PNIPAM is considered advantageous because of the assumed lower toxicity of PNVCL. PNVCL copolymer gels are sensitive to external stimuli, such as temperature and pH; which gives them a wide range of biomedical applications and consequently attracts considerable scientific interest. This review focuses on the recent studies on PNVCL-based stimuli responsive three dimensional hydrogels (macro, micro, and nano) for biomedical applications. This review also covers the future outlooks of PNVCL-based gels for biomedical applications, particularly in the drug delivery field.

引用

页数：19

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