CHANGES INDUCED BY TREATMENT WITH AROMATASE INHIBITORS IN TESTICULAR LEYDIG-CELLS OF RATS AND DOGS

被引：19

作者：

WALKER, UJ

NOGUES, V

机构：

[1] Pharma Division, Ciba-Geigy AG, Basel

来源：

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY | 1994年 / 46卷 / 03期

关键词：

AROMATASE INHIBITORS; LEYDIG CELLS; TESTICULAR; TESTICULAR LEYDIG CELLS;

D O I：

10.1016/S0940-2993(11)80083-7

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Treatment of male rats and dogs with CGP 32 349 (formestane), a steroidal aromatase inhibitor, and CGS 20 267 (letrozole), a non-steroidal aromatase inhibitor, induced different alterations in testicular interstitial Leydig cells in the two species. Whereas in dogs Leydig cells were hypertrophic and hyperplastic, in rats either no effect (CGS 20 267) or atrophy of Leydig cells (CGP 32 349) was reported. The different response of the two species can be explained by different regulating mechanisms of gonadotropin secretion by the anterior pituitary.

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收藏

页码：211 / 213

页数：3

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