COLOCALIZATION OF FGF-2 AND A NOVEL HEPARAN-SULFATE PROTEOGLYCAN IN EMBRYONIC MOUSE-BRAIN

被引：24

作者：

FORD, MD ^{[1
]}

BARTLETT, PF ^{[1
]}

NURCOMBE, V ^{[1
]}

机构：

[1] ROYAL MELBOURNE HOSP,WALTER & ELIZA HALL INST MED RES,MELBOURNE,VIC 3050,AUSTRALIA

来源：

NEUROREPORT | 1994年 / 5卷 / 05期

关键词：

HEPARAN SULFATE PROTEOGLYCAN; NEUROEPITHELIUM; FIBROBLAST GROWTH FACTOR; EXTRACELLULAR MATRIX; GLYCOSAMINOGLYCANS;

D O I：

10.1097/00001756-199401000-00008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

NEURAL precursor cells are known to be greatly stimulated during their development by members of the fibroblast growth factor (FGF) family of growth factors. FGF activity is regulated by essential interactions with a low affinity class of receptors called heparan sulphate proteoglycans (HSPGs), which modulate subsequent binding to the high affinity signal transducing receptors. We have purified a novel species of secreted HSPG and generated specific polyclonal antibodies against its core protein. The HSPG exactly co-localizes with FGF-2 within the neuroepithelium of the embryonic mouse. The results support the concept that HSPGs play crucial roles in regulating neural cell responses to particular growth factors.

引用

页码：565 / 568

页数：4

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