Mechanisms of heritable gene repression during development of Drosophila

被引：115
作者：
Paro, Renato [1 ]
机构：
[1] Univ Heidelberg, Zentrum Mol Biol, D-69120 Heidelberg, Germany
来源：
CURRENT OPINION IN CELL BIOLOGY | 1993年 / 5卷 / 06期
关键词：
D O I：
10.1016/0955-0674(93)90084-4
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
During development, patterns of differential gene expression, defining determined states of cells, need to be maintained over many cell generations. In Drosophila, genetic and molecular analyses led to the discovery of a set of proteins which seem to exert such a memory function by using epigenetic mechanisms. Recent experiments demonstrate that, in particular, the heritable inactivation of regulatory genes relies on stable changes in the higher-order constitution of chromatin.
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页码：999 / 1005
页数：7
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