OCCUPATIONAL ASTHMA TO THE SLIME-MOLD DICTYOSTELIUM-DISCOIDEUM

被引：0

作者：

GOTTLIEB, SJ ^{[1
]}

GARIBALDI, E ^{[1
]}

HUTCHESON, PS ^{[1
]}

SLAVIN, RG ^{[1
]}

机构：

[1] ST LOUIS UNIV,SCH MED,DIV ALLERGY & IMMUNOL,ST LOUIS,MO 63104

来源：

JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE | 1993年 / 35卷 / 12期

关键词：

D O I：

暂无

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Dictyostelium discoideum is a slime mold that exists in a unicellular amoeboid form under certain nutritional conditions. In this form, it produces unique lysosomal enzymes that are valuable in studying cell-to-cell signaling systems. We report on a research microbiologist who developed rhinoconjunctivitis and asthma after release of D. discoideum from a pressurized canister. Immediate skin test reactivity was demonstrated to whole and lysed organisms. Enzyme-linked immunosorbent assay results revealed IgE antibody against D. discoideum whole organism, lysed organism, and lysosomal enzymes with the strongest response being directed toward lysosomal enzymes. Pulmonary function testing showed a decline in forced expiratory volume in I second and forced expiratory flow after modified laboratory exposure to D. discoideum. This case represents the first report of occupational rhinoconjunctivitis and asthma from slime mild.

引用

页码：1231 / 1235

页数：5

共 25 条

[11]

GILBERT SF, 1988, DEV BIOL, P21

[12]

HARINDRANATH N, 1985, ANN ALLERGY, V55, P511

[13] PANCREATIC EXTRACT LUNG SENSITIVITY [J].

HILL, D .

MEDICAL JOURNAL OF AUSTRALIA, 1975, 2 (14) :553-555

[14]

JONES RN, 1982, AM REV RESPIR DIS, V125, P199

[15] PULMONARY AND IMMUNOLOGICAL EVALUATION OF FOUNDRY WORKERS EXPOSED TO METHYLENE DIPHENYLDIISOCYANATE (MDI) [J].

LISS, GM ;

BERNSTEIN, DI ;

MOLLER, DR ;

GALLAGHER, JS ;

STEPHENSON, RL ;

BERNSTEIN, IL .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1988, 82 (01) :55-61

[16] ACUTE BRONCHIAL-ASTHMA - RELATIONS BETWEEN CLINICAL AND PHYSIOLOGIC MANIFESTATIONS [J].

MCFADDEN, ER ;

KISER, R ;

DEGROOT, WJ .

NEW ENGLAND JOURNAL OF MEDICINE, 1973, 288 (05) :221-225

[17]

NEWHOUSE ML, 1970, LANCET, V1, P689

[18]

Pepys J, 1972, Clin Allergy, V2, P391, DOI 10.1111/j.1365-2222.1972.tb01303.x

[19]

RUBINFELD AR, 1976, LANCET, V1, P882

[20]

Slavin R G, 1989, J Allergy Clin Immunol, V84, P1059, DOI 10.1016/0091-6749(89)90153-X

← 1 2 3 →