BOX-COX TRANSFORMATION IN THE ANALYSIS OF COMBINED EFFECTS OF MIXTURES OF CHEMICALS

被引：3

作者：

RAZZAGHI, M

KODELL, RL

机构：

[1] Department of Mathematics, Bloomsburg University of Pennsylvania, Bloomsburg, Pennsylvania

[2] National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas

来源：

ENVIRONMETRICS | 1992年 / 3卷 / 03期

关键词：

BOX-COX TRANSFORMATION; JOINT ACTION; MIXTURES;

D O I：

10.1002/env.3170030305

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

A new general approach to modelling the joint action of two non-interactive toxicants is considered. It is shown that the proposed method provides a more refined characterization of a mixture of two chemicals. The method is based on using the Box-Cox power transformation to derive the most suitable function of concentration to be used in a linear response function obtained from a linearizing transformation. The concepts of concentration a-nd response additivity as two extreme cases of additive joint action are discussed and used to demonstrate the ideas of an ''envelope of additivity''. Two examples are used to provide further illustration of the proposed approach.

引用

页码：319 / 334

页数：16

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