C-13 NUCLEAR MAGNETIC-RESONANCE STUDY OF PROTONATION OF METHOTREXATE AND AMINOPTERIN BOUND TO DIHYDROFOLATE-REDUCTASE

被引：86
作者：
COCCO, L
GROFF, JP
TEMPLE, C
MONTGOMERY, JA
LONDON, RE
MATWIYOFF, NA
BLAKLEY, RL
机构：
[1] UNIV IOWA,COLL MED,DEPT BIOCHEM,IOWA CITY,IA 52242
[2] SO RES INST,BIRMINGHAM,AL 35205
[3] UNIV CALIF LOS ALAMOS SCI LAB,LOS ALAMOS,NM 87545
来源：
BIOCHEMISTRY | 1981年 / 20卷 / 14期
关键词：
D O I：
10.1021/bi00517a005
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：3972 / 3978
页数：7
相关论文
共 39 条
[1]   ABSOLUTE-CONFIGURATION OF 6-METHYL-5,6,7,8-TETRAHYDROPTERIN PRODUCED BY ENZYMIC REDUCTION (DIHYDROFOLATE-REDUCTASE AND NADPH) OF 6-METHYL-7,8-DIHYDROPTERIN [J].
ARMAREGO, WLF ;
WARING, P ;
WILLIAMS, JW .
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1980, (08) :334-336
[2]  
BAKER BERNARD R., 1959, CANCER CHEMOTHERAPY REPTS, V4, P1
[3]  
BAKER BR, 1967, DESIGN ACTIVESITEDIR, pCH10
[4]   MECHANISM OF ALCOHOL DEHYDROGENASES FROM YEAST AND HORSE LIVER [J].
BIELLMAN.JF ;
JUNG, MJ .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1971, 19 (01) :130-&
[5]  
BLAKLEY RL, 1978, BIOCHEMISTRY-US, V17, P2284, DOI 10.1021/bi00605a005
[6]  
BLAKLEY RL, 1981, 2ND P ANN BRIST MEY, P303
[7]   STUDIES OF HISTIDINE RESIDUES OF TRIOSE PHOSPHATE ISOMERASE BY PROTON MAGNETIC-RESONANCE AND X-RAY CRYSTALLOGRAPHY [J].
BROWNE, CA ;
CAMPBELL, ID ;
KIENER, PA ;
PHILLIPS, DC ;
WALEY, SG ;
WILSON, IA .
JOURNAL OF MOLECULAR BIOLOGY, 1976, 100 (03) :319-343
[8]   STEREOCHEMISTRY OF REDUCTION OF FOLIC-ACID USING DIHYDROFOLATE-REDUCTASE [J].
CHARLTON, PA ;
YOUNG, DW ;
BIRDSALL, B ;
FEENEY, J ;
ROBERTS, GCK .
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1979, (20) :922-924
[9]  
CLELAND WW, 1967, ADV ENZYMOL RAMB, V29, P1
[10]   ROLES OF ZINC ION AND REDUCED COENZYME IN HORSE LIVER ALCOHOL-DEHYDROGENASE CATALYSIS - MECHANISM OF ALDEHYDE ACTIVATION [J].
DUNN, MF ;
BIELLMANN, JF ;
BRANLANT, G .
BIOCHEMISTRY, 1975, 14 (14) :3176-3182
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