NUCLEOTIDE REGULATION OF VASOACTIVE-INTESTINAL-PEPTIDE BINDING TO BOVINE THYROID PLASMA-MEMBRANES

被引：6
作者：
CALVO, JR
MORALES, MF
MESA, JC
GOBERNA, R
机构：
[1] Department of Medical Biochemistry and Molecular Biology, School of Medicine, University of Sevilla, Sevilla, 4 41009, Avda. Sánchez Pizjuán
来源：
BIOSCIENCE REPORTS | 1990年 / 10卷 / 06期
关键词：
VASOACTIVE INTESTINAL PEPTIDE BINDING; THYROID PLASMA MEMBRANES; NUCLEOTIDE REGULATION;
D O I：
10.1007/BF01116612
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The specific binding of vasoactive intestinal peptide (VIP) to bovine thyroid plasma membranes is inhibited by guanine nucleotides. Guanosine 5'-triphosphate (GTP) and the non-hydrolyzable GTP analogs guanosine 5'-beta,gamma-imidotriphosphate (Gpp(NH)p) and guanosine 5'-O-(3-thiotriphosphate) (GTP-gamma-S) inhibited markedly the binding of VIP to its receptors. This inhibition was higher with GTP than with Gpp(NH)p and GTP-gamma-S and was due to an increase of the rate of dissociation of peptide bound to membranes. Other nucleotides did not show any effect.
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收藏
页码：519 / 525
页数：7
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