STRATEGIES FOR MAPPING AND IMITATING VIRAL B-CELL EPITOPES

被引：13
作者：
CASON, J
机构：
[1] The Richard Dimbleby Laboratory for Cancer Virology, The Rayne Institute, St Thomas' Hospital, London, SE1 7EH, Lambeth Palace Road
来源：
JOURNAL OF VIROLOGICAL METHODS | 1994年 / 49卷 / 02期
关键词：
VIRUS; EPITOPE MAPPING; ANTIBODY;
D O I：
10.1016/0166-0934(94)90045-0
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Identification of viral B-cell epitopes is of importance in the selection of peptides for inclusion into subunit vaccines, the development of virus-specific serological tests and understanding the interaction of antibodies with viruses at a molecular level. B-cell epitopes can often be determined unequivocally by X-ray analyses of antibody-antigen complexes. This technique is, however, time-consuming and alternative strategies have now been developed for identifying epitopes. This article provides an overview of approaches which are currently available for mapping and imitating B-cell epitopes.
引用
收藏
页码：209 / 219
页数：11
相关论文
共 41 条
  • [1] MONOCLONAL-ANTIBODIES AS PROBES OF THE ANTIGENIC STRUCTURE OF TOBACCO MOSAIC-VIRUS
    ALMOUDALLAL, Z
    BRIAND, JP
    VANREGENMORTEL, MHV
    [J]. EMBO JOURNAL, 1982, 1 (08) : 1005 - 1010
  • [2] DETECTION OF ANTIBODY TO HEPATITIS-C VIRUS IN PROSPECTIVELY FOLLOWED TRANSFUSION RECIPIENTS WITH ACUTE AND CHRONIC NON-A-HEPATITIS, NON-B-HEPATITIS
    ALTER, HJ
    PURCELL, RH
    SHIH, JW
    MELPOLDER, JC
    HOUGHTON, M
    CHOO, QL
    KUO, G
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (22) : 1494 - 1500
  • [3] THE AMINO TERMINUS OF HUMAN CYTOMEGALOVIRUS GLYCOPROTEIN-B CONTAINS EPITOPES THAT VARY AMONG STRAINS
    BASGOZ, N
    QADRI, I
    NAVARRO, D
    SEARS, A
    LENNETTE, E
    YOUNGBLOM, J
    PEREIRA, L
    [J]. JOURNAL OF GENERAL VIROLOGY, 1992, 73 : 983 - 988
  • [4] 3-DIMENSIONAL STRUCTURE OF AN IDIOTOPE ANTI-IDIOTOPE COMPLEX
    BENTLEY, GA
    BOULOT, G
    RIOTTOT, MM
    POLJAK, RJ
    [J]. NATURE, 1990, 348 (6298) : 254 - 257
  • [5] BOEHRINGER, 1991, BOEHRINGER MANNHEIM
  • [6] EXPRESSION OF HUMAN PAPILLOMAVIRUS PROTEINS IN YEAST SACCHAROMYCES CEREVISIAE
    CARTER, JJ
    YAEGASHI, N
    JENISON, SA
    GALLOWAY, DA
    [J]. VIROLOGY, 1991, 182 (02) : 513 - 521
  • [7] IDENTIFICATION OF IMMUNOGENIC REGIONS OF THE MAJOR COAT PROTEIN OF HUMAN PAPILLOMAVIRUS TYPE-16 THAT CONTAIN TYPE-RESTRICTED EPITOPES
    CASON, J
    PATEL, D
    NAYLOR, J
    LUNNEY, D
    SHEPHERD, PS
    BEST, JM
    MCCANCE, DJ
    [J]. JOURNAL OF GENERAL VIROLOGY, 1989, 70 : 2973 - 2987
  • [8] MAPPING OF LINEAR B-CELL EPITOPES ON CAPSID PROTEINS OF BOVINE PAPILLOMAVIRUS - IDENTIFICATION OF 3 EXTERNAL TYPE-RESTRICTED EPITOPES
    CASON, J
    KAMBO, PK
    JEWERS, RJ
    CHRYSTIE, IL
    BEST, JM
    [J]. JOURNAL OF GENERAL VIROLOGY, 1993, 74 : 2669 - 2677
  • [9] ISOLATION OF A CDNA CLONE DERIVED FROM A BLOOD-BORNE NON-A, NON-B VIRAL-HEPATITIS GENOME
    CHOO, QL
    KUO, G
    WEINER, AJ
    OVERBY, LR
    BRADLEY, DW
    HOUGHTON, M
    [J]. SCIENCE, 1989, 244 (4902) : 359 - 362
  • [10] PEPTIDES ON PHAGE - A VAST LIBRARY OF PEPTIDES FOR IDENTIFYING LIGANDS
    CWIRLA, SE
    PETERS, EA
    BARRETT, RW
    DOWER, WJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (16) : 6378 - 6382
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