SYNTHESIS OF MODIFIED DISACCHARIDE AND TRISACCHARIDE FRAGMENTS OF N-GLYCOPROTEINS

被引：9

作者：

SPIJKER, NM

SLIEF, JW

VANBOECKEL, CAA

机构：

[1] Organon International, Scientific Development Group, 5340 BH Oss

来源：

JOURNAL OF CARBOHYDRATE CHEMISTRY | 1993年 / 12卷 / 08期

关键词：

D O I：

10.1080/07328309308020115

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The syntheses of several analogues of disaccharide Manalpha(1-->6)Manalpha-OCH3 (1) and of trisaccharide Manalpha(1-->6)[Manalpha(1-->3)]Manalpha-OCH3 (2) are reported. The syntheses are described of the diastereomeric 6-methyl derivatives 9a and 9b, which are representatives of fixed conformations of disaccharide 1. The syntheses of the 2-amino-2-deoxy analogues 15 and 17 and the synthesis of the 2-fluoro-2-deoxy analogue 28 are also reported.

引用

页码：1017 / 1041

页数：25

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