SALMONELLA AND THEIR DISEASES - BACTERIOLOGICAL BASIS OF THE TREATMENT

The ideal antibiotic for salmonellosis will associate a good tissular diffusion, a good intracellular concentration with good bacteriological activity. A low MIC, a rapid bactericidal action on bacteria in growing phase as well as bacteria in quiet phase, the absence of resistance selection, a long post-antibiotic effect and a synergetic association with other bactericidal antibiotics, are the principal data studied by the bacteriologist. Fluoroquinolones are the antibiotics which can be considered as the nearest from the ideal one, followed by the third generation cephalosporins. The emergence of in vivo resistance on Salmonella should create an increased vigilance in therapeutic strategies and in epidemiologic supervision.