A 3-DEAZAURACIL-RESISTANT MUTANT OF BACILLUS-SUBTILIS WITH INCREASED PRODUCTION OF CYTIDINE

被引：13

作者：

ASAHI, S

TSUNEMI, Y

IZAWA, M

DOI, M

机构：

[1] Fermentation Center, Technology Development Laboratories, Takeda Chemical Industries Ltd., Yodogawa-ku

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1995年 / 59卷 / 05期

关键词：

D O I：

10.1271/bbb.59.915

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bacillus subtilis No, 344 is a cytidine-producing mutant strain derived from wild type strain No. 122, When 3-deazauracil-resistant mutants were derived from strain No, 344, some of the mutants had higher productivities of cytidine. Among them, strain No, 428 accumulated 14.2 mg/ml cytidine in the culture. Cytidine 5'-triphosphate (CTP) synthetase from strain No, 428 changed to be free from feedback inhibition by CTP, compared with the enzyme from strain No, 344.

引用

页码：915 / 916

页数：2

共 8 条

[1] MICROBIAL-PRODUCTION OF URIDINE .2. REGULATION OF PYRIMIDINE NUCLEOTIDE BIOSYNTHESIS IN CYTIDINE DEAMINASE-NEGATIVE MUTANTS OF BACILLUS-SUBTILIS [J].