DOPAMINE RELEASE IN THE NUCLEUS-ACCUMBENS - THE PERSPECTIVE FROM ABERRATIONS OF CONSCIOUSNESS IN SCHIZOPHRENIA

被引:56
|
作者
GRAY, JA
机构
基金
英国惠康基金;
关键词
NUCLEUS ACCUMBENS; SCHIZOPHRENIA; DOPAMINE; CONSCIOUSNESS; RETROHIPPOCAMPAL REGION;
D O I
10.1016/0028-3932(95)00054-7
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Studies of the cognitive abnormalities that underlie positive symptoms in acute schizophrenia, and animal experiments that attempt to model similar cognitive abnormalities and to elucidate the brain mechanisms underlying them, suggest that the release of dopamine from A 10 terminals in the nucleus (n.) accumbens, in interaction with the projection to n. accumbens from the retrohippocampal region, is closely related to stimulus salience and perhaps to the heightened states of awareness reported by schizophrenics.
引用
收藏
页码:1143 / 1153
页数:11
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