MAPPING OF THE ALPHA(4) SUBUNIT GENE (GABRA4) TO HUMAN-CHROMOSOME-4 DEFINES AN ALPHA(2)-ALPHA(4)-BETA(1)-GAMMA(1) GENE-CLUSTER - FURTHER EVIDENCE THAT MODERN GABA(A) RECEPTOR GENE CLUSTERS ARE DERIVED FROM AN ANCESTRAL CLUSTER

被引：58

作者：

MCLEAN, PJ ^{[1
]}

FARB, DH ^{[1
]}

RUSSEK, SJ ^{[1
]}

机构：

[1] BOSTON UNIV,SCH MED,DEPT PHARMACOL,MOLEC NEUROBIOL LAB,BOSTON,MA 02118

来源：

GENOMICS | 1995年 / 26卷 / 03期

关键词：

D O I：

10.1016/0888-7543(95)80178-O

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We demonstrated previously that an alpha(1)-beta(2)-gamma(2) gene cluster of the gamma-aminobutyric acid (GABA(A)) receptor is located on human chromosome 5q34-q35 and that an ancestral alpha-beta-gamma gene cluster probably spawned clusters on chromosomes 4, 5, and 15. Here, we report that the alpha(4) gene (GABRA4) maps to human chromosome 4p14-q12, defining a cluster comprising the alpha(2), alpha(4), beta(1), and gamma(1) genes. The existence of an alpha(2)-alpha(4)-beta(1)-gamma(1) cluster on chromosome 4 and an alpha(1)-alpha(6)-beta(2)-gamma(2) cluster on chromosome 5 provides further evidence that the number of ancestral GABA(A) receptor subunit genes has been expanded by duplication within an ancestral gene cluster. Moreover, if duplication of the alpha gene occurred before duplication of the ancestral gene cluster, then a heretofore undiscovered subtype of alpha subunit should be located on human chromosome 15q11-q13 within an alpha(5)-alpha(x)-beta(3)-gamma(3) gene cluster at the locus for Angelman and Prader-Willi syndromes. (C) 1995 Academic Press, Inc.

引用

页码：580 / 586

页数：7

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