EFFECT OF SYNTHETIC ANALOGS OF DERMORPHIN ON MITOSIS IN THE CORNEAL AND LINGUAL EPITHELIUM OF ALBINO-RATS

被引：0
|
作者：
FLEISHMAN, MY [1 ]
RADIVOZ, MI [1 ]
TIMOSHIN, S [1 ]
YAROVA, EP [1 ]
KESELMAN, SA [1 ]
机构：
[1] MED INST,CENT RES LAB,KHABAROVSK,RUSSIA
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1994年 / 118卷 / 11期
关键词：
DEMORPHIN; DNA SYNTHESIS; MITOSIS;
D O I：
10.1007/BF02444626
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
A study of the effects of synthetic analogs of dermorphin which are prime agonists of the mu-opiate receptors, on cell division in the corneal and lingual epithelium of albino rats showed that both analogs depressed DNA synthesis in the corneal and lingual epithelium 4 h after administration. In the lingual epithelium DNA synthesis and the mitogenic index were still depressed 24 h after drug administration. In the cornea cell division parameters had normalized by this time.
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页码：1205 / 1207
页数：3
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