MURINE CHROMOSOMAL LOCATION OF 5 BHLH-ZIP TRANSCRIPTION FACTOR GENES

被引：19

作者：

STEINGRIMSSON, E

SAWADOGO, M

GILBERT, DJ

ZERVOS, AS

BRENT, R

BLANAR, MA

FISHER, DE

COPELAND, NG

JENKINS, NA

机构：

[1] NCI,FREDERICK CANC RES & DEV CTR,ABL BASIC RES PROGRAM,MAMMALIAN GENET LAB,FREDERICK,MD 21702

[2] UNIV TEXAS,MD ANDERSON CANC CTR,DEPT MOLEC GENET,HOUSTON,TX 77030

[3] HARVARD UNIV,SCH MED,DEPT GENET,BOSTON,MA 02114

[4] MASSACHUSETTS GEN HOSP,DEPT MOLEC BIOL,BOSTON,MA 02114

[5] BRISTOL MYERS SQUIBB PHARMACEUT RES INST,DEPT CARDIOVASC MOLEC & CELLULAR BIOL,PRINCETON,NJ 08543

[6] DANA FARBER CANC INST,BOSTON,MA 02115

来源：

GENOMICS | 1995年 / 28卷 / 02期

关键词：

D O I：

10.1006/geno.1995.1129

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The genes for the bHLH-Zip transcription factors Tfap4, Mxi1, Tcfeb, Usf1, and Usf2 have been mapped in mouse by interspecific backcross analysis. Mxi1, Usf1, and Usf2 have been mapped previously by in situ hybridization, but their positions on the meiotic linkage map had not been determined, The other two genes have not previously been mapped in mouse. These transcription factors belong to a growing family of transcriptional regulators, some of which are known to form a complex network of interacting proteins that control cell proliferation and apoptosis. As expected, based on mapping studies of other bHLH-Zip genes, these loci were well distributed among mouse chromosomes. In addition, some of the probes used in this study detected multiple, independently segregating loci, suggesting the possible existence of additional family members or species-specific pseudogenes. (C) 1995 Academic Press, Inc.

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页码：179 / 183

页数：5

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