HEAVY-CHAIN VARIABLE REGION CONTRIBUTION TO THE NPB FAMILY OF ANTIBODIES - SOMATIC MUTATION EVIDENT IN A GAMMA-2A VARIABLE REGION

被引：716
作者：
BOTHWELL, ALM
PASKIND, M
RETH, M
IMANISHIKARI, T
RAJEWSKY, K
BALTIMORE, D
机构：
[1] MIT,DEPT BIOL,CAMBRIDGE,MA 02139
[2] UNIV COLOGNE,INST GENET,D-5000 COLOGNE 41,FED REP GER
来源：
CELL | 1981年 / 24卷 / 03期
关键词：
D O I：
10.1016/0092-8674(81)90089-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：625 / 637
页数：13
相关论文
共 48 条
[1]  
ADETUGBO K, 1978, J BIOL CHEM, V253, P6068
[2]  
ALTMAN PL, 1979, INBRED GENETICALLY 1, P15
[3]  
Alwine J C, 1979, Methods Enzymol, V68, P220
[4]   SEQUENCES OF MOUSE IMMUNOGLOBULIN LIGHT CHAIN GENES BEFORE AND AFTER SOMATIC CHANGES [J].
BERNARD, O ;
HOZUMI, N ;
TONEGAWA, S .
CELL, 1978, 15 (04) :1133-1144
[5]   NUCLEOTIDE-SEQUENCE OF IMMUNOGLOBULIN HEAVY-CHAIN JOINING SEGMENTS BETWEEN TRANSLOCATED VH AND MU-CONSTANT REGION GENES [J].
BERNARD, O ;
GOUGH, NM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (06) :3630-3634
[6]  
COHN M, 1971, CELL IMMUNOL, V1, P461
[7]   SOMATIC REARRANGEMENTS FORMING ACTIVE IMMUNOGLOBULIN MU-GENES IN B-LYMPHOID AND T-LYMPHOID CELL-LINES [J].
CORY, S ;
ADAMS, JM ;
KEMP, DJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (08) :4943-4947
[8]   DELETIONS ARE ASSOCIATED WITH SOMATIC REARRANGEMENT OF IMMUNOGLOBULIN HEAVY-CHAIN GENES [J].
CORY, S ;
ADAMS, JM .
CELL, 1980, 19 (01) :37-51
[9]  
CUNNINGHAM AJ, 1978, UNDERSTANDING IMMUNO
[10]   AN IMMUNOGLOBULIN HEAVY-CHAIN VARIABLE REGION GENE IS GENERATED FROM 3 SEGMENTS OF DNA - VH, D AND JH [J].
EARLY, P ;
HUANG, H ;
DAVIS, M ;
CALAME, K ;
HOOD, L .
CELL, 1980, 19 (04) :981-992
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