SUBSENSITIVITY TO REWARDING AND LOCOMOTOR STIMULANT EFFECTS OF A DOPAMINE AGONIST FOLLOWING CHRONIC MILD STRESS

被引：67
作者：
PAPP, M [1 ]
MUSCAT, R [1 ]
WILLNER, P [1 ]
机构：
[1] CITY LONDON POLYTECH, DEPT PSYCHOL, OLD CASTLE ST, LONDON E1 7NT, ENGLAND
来源：
PSYCHOPHARMACOLOGY | 1993年 / 110卷 / 1-2期
关键词：
STRESS; PLACE PREFERENCE CONDITIONING; REWARD; LOCOMOTOR ACTIVITY; AMPHETAMINE; QUINPIROLE; DOPAMINE; D2; RECEPTOR; NUCLEUS ACCUMBENS;
D O I：
10.1007/BF02246965
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Chronic exposure to very mild unpredictable stress has previously been found to reduce or abolish the acquisition of place preference conditioning. In the present study, chronic mild stress was found to abolish the acquisition of preferences for a distinctive environment paired with systemic administration of amphetamine (0.5 mg/kg) or quinpirole (100-400 mug/kg) or with quinpirole (0.75 mug) administered bilaterally within the nucleus accumbens. The locomotor stimulant effects of quinpirole (100-400 mug/kg) were also attenuated in stressed animals. The results suggest that decreased sensitivity to reward following chronic mild stress results from a decreased sensitivity of dopamine D2 receptors within the nucleus accumbens.
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页码：152 / 158
页数：7
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