INFLUENCE OF HLA COMPATIBILITY ON KIDNEY-TRANSPLANTATION

被引：0

作者：

OPELZ, G

WUJCIAK, T

BACK, D

MYTILINEOS, J

SCHWARZ, V

ALBRECHT, G

机构：

来源：

INFUSIONSTHERAPIE UND TRANSFUSIONSMEDIZIN | 1994年 / 21卷 / 03期

关键词：

HLA COMPATIBILITY; HLA TYPING; KIDNEY TRANSPLANTATION;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The influence of the HLA system on the success rate of kidney transplantations was evaluated in a worldwide collaborative study. The results confirm the influence of the HLA chromosome on transplants from related donors. Moreover, a highly significant effect of compatibility for the HLA-A, -B, -DR antigens was observed in cadaver transplants (p < 0.0001). The great importance of a good quality of tissue typing was emphasized by a) the observation that a significant influence of compatibility for the HLA-A, -B antigens was evident only if donors and recipients were typed for 'split' specificities and not when they were typed for 'broad' antigens, and b) an improved effect of HLA-DR compatibility when serological typing errors were corrected by molecular (DNA) typing. Computations show that kidney allocation according to the best possible HLA compatibility results in a gain of 800 transplant function years per 1,000 transplantations over a 10-year period.

引用

页码：198 / 202

页数：5

共 8 条

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