EVOLUTION OF THE VERTEBRATE GENOME AS REFLECTED IN PARALOGOUS CHROMOSOMAL REGIONS IN MAN AND THE HOUSE MOUSE

被引：402
作者：
LUNDIN, LG
机构：
[1] Department of Medical and Physiologi, Biomedical Centre, University of Uppsala, S-751 23 Uppsala
来源：
GENOMICS | 1993年 / 16卷 / 01期
关键词：
D O I：
10.1006/geno.1993.1133
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Gene constellations on several human chromosomes are interpreted as indications of large regional duplications that took place during evolution of the vertebrate genome. Four groups of paralogous chromosomal regions in man and the house mouse are suggested and are believed to be conserved remnants of the two or three rounds of tetraploidization that are likely to have occurred during evolution of the vertebrates. The phenomenon of differential silencing of genes is described. The importance of conservation of linkage of particular genes is discussed in relation to genetic regulation and cell differentiation. © 1993 Academic Press, Inc.
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页码：1 / 19
页数：19
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