RENAL-FUNCTION AFTER HIP-ARTHROPLASTY AND ISOXAZOLYLPENICILLIN PROPHYLAXIS

被引：4

作者：

WAHLSTROM, O ^{[1
]}

MALLER, R ^{[1
]}

DJERF, K ^{[1
]}

IVARSSON, I ^{[1
]}

机构：

[1] LINKOPING UNIV HOSP,FAC HLTH SCI,DEPT INFECT DIS,S-58185 LINKOPING,SWEDEN

来源：

ACTA ORTHOPAEDICA SCANDINAVICA | 1992年 / 63卷 / 05期

关键词：

D O I：

10.3109/17453679209154732

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Two different isoxazolylpenicillins (cloxacillin and dicloxacillin) were compared regarding impairment of renal function after total hip arthroplasty. 85 patients received dicloxacillin and 93 patients received cloxacillin as antibiotic prophylaxis. A total dose of 6 grams was given during a 36-hour period in doses of 1 gram pre-, per- and postoperatively. Creatinine in serum and beta2-microglobulin in serum and urine were determined preoperatively and 2, 4, and 1 0 days after the operation. The dicloxacillin-treated patients had an increase in creatinine and beta2-microglobulin in serum that was not seen in the cloxacillin group. The increase indicates a transient injury in the process of glomerular filtration. Although the increase was temporary and subclinical, a dose reduction is nevertheless recommended for older patients.

引用

页码：539 / 542

页数：4

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