ECHINOMYCIN (NSC 526417) IN RECURRENT AND METASTATIC NONSQUAMOUS CELL-CARCINOMA OF THE CERVIX - A PHASE-II TRIAL OF THE GYNECOLOGIC ONCOLOGY GROUP

被引：7

作者：

MUSS, HB

BLESSING, JA

HANJANI, P

MALFETANO, JH

KEMP, GM

WEBSTER, K

机构：

[1] WAKE FOREST UNIV,BOWMAN GRAY SCH MED,WINSTON SALEM,NC 27103

[2] ROSWELL PK CANC INST,GYNECOL ONCOL GRP,BUFFALO,NY

[3] TEMPLE UNIV,HLTH SCI CTR,PELVIC ONCOL SECT,PHILADELPHIA,PA 19140

[4] ALBANY MED CTR HOSP,DEPT OBSTET & GYNECOL,ALBANY,NY 12208

[5] EASTERN VIRGINIA MED SCH,DEPT OBSTET & GYNECOL,DIV GYNECOL ONCOL,NORFOLK,VA 23501

[6] CLEVELAND CLIN EDUC FDN,DEPT GYNECOL,CLEVELAND,OH 44106

来源：

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS | 1992年 / 15卷 / 04期

关键词：

ECHINOMYCIN; NONSQUAMOUS CELL CARCINOMA; CERVIX CANCER; PHASE-II TRAIL;

D O I：

10.1097/00000421-199208000-00019

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Eighteen evaluable patients with recurrent or metastatic nonsquamous carcinoma of the uterine cervix were treated with 1,500-mu-g/m2 of echinomycin every 4 weeks. Seven patients had received prior chemotherapy. There was one complete response (5.6%), 95% confidence interval for response of 0-27%. The major toxicity was nausea and vomiting, which was moderate to severe in eight patients. Myelosuppression was minimal. Echinomycin in this dose and schedule displays minimal activity in patients with advanced nonsquamous carcinoma of the cervix.

引用

页码：363 / 364

页数：2

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