LITHIUM AS AN ADJUNCT IN THE TREATMENT OF MAJOR DEPRESSION

被引：29

作者：

BROWNE, M

LAPIERRE, YD

HRDINA, PD

HORN, E

机构：

[1] UNIV OTTAWA, DEPT PHARMACOL, OTTAWA K1N 6N5, ONTARIO, CANADA

[2] UNIV OTTAWA, DEPT PSYCHIAT, OTTAWA K1N 6N5, ONTARIO, CANADA

[3] ROYAL OTTAWA HOSP, PSYCHOPHARMACOL UNIT, OTTAWA K1Z 7K4, ONTARIO, CANADA

来源：

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY | 1990年 / 5卷 / 02期

关键词：

D O I：

10.1097/00004850-199004000-00004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This paper reports a double-blind cross-over study (1) to investigate the efficacy of lithium carbonate to produce rapid relief of major depression in patients who were previously unresponsive to at least 4 weeks of antidepressant therapy; (2) to study the effect of acute lithium administration on antidepressant blood levels. In contrast to other studies, lithium was found to be no more effective than placebo. The effect of lithium adjunct on antidepressant levels was not significant. © 1990 CNS (Clinical Neuroscience) Publishers.

引用

页码：103 / 110

页数：8

共 14 条

[1]

BALDESSARINI RJ, 1979, AM J PSYCHIAT, V136, P1177

[2] LITHIUM INDUCES RAPID RELIEF OF DEPRESSION IN TRICYCLIC ANTI-DEPRESSANT DRUG NON-RESPONDERS [J].