Effects of Ginger Solvent in Alloxan Induced Diabetic Nephropathy in Rats

Aim: To appraise the effects of Ginger solvent extract on Renal corpuscle number and diameter in Alloxan induced diabetic nephropathy of albino rats. Place of study: study was conducted Federal postgraduate Medical Institute of Shaikh Zayed hospital and National Health Research Complex Lahore Methods: 45 adult male wistar albino rats having weight between 250-300g were indiscriminately chosen for the study.. Animals were housed in standard cages. They were allowed free access to water and standard diet under controlled conditions of temperature 25 +/- 2 and normal photoperiod (12 hours dark and light) throughout the experiment. Intraperitoneal injection of Alloxan (150 mg/kg body weight) was used to induce diabetes mellitus in albino rats of investigational groups B & C. Results: Number of renal corpuscles per mm2 were more decreased and the diameter of renal corpuscle was more increased in investigational group B than group C. Group association between control and investigationalgroups B & C. Conclusion:.Ginger role was significant in renal diabetic nephropathy It is due to the antioxidants components counteraction by free radicals and it also helps in improvement of increased blood sugar levels in blood with the help of pancreatic and extra pancreatic mechanisms.