STRUCTURAL ELUCIDATION OF TRIKONINGIN-KA AND TRIKONINGIN-KB, PEPTAIBOLS FROM TRICHODERMA-KONINGII

被引：39

作者：

AUVINGUETTE, C

REBUFFAT, S

VUIDEPOT, I

MASSIAS, M

BODO, B

机构：

[1] Laboratoire de Chimie, URA 401 CNRS, Muséum National d'Histoire Naturelle, 75231 Paris Cedex 05

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1993年 / 02期

关键词：

D O I：

10.1039/p19930000249

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Trichoderma koningii strain collected in Uruguay produced two antibiotic membrane-active peptidic groups, the trikoningins KA and KB, from which the main components KA V, KB I and KB II were purified. The peptide sequences were elucidated by FAB mass spectrometry and high-field NMR experiments. KA V was a nonadecapeptaibol, whereas KB I and KB II were two 11-residue lipopeptaibols. They all displayed antibiotic activity against Staphylococcus aureus. Their membrane-modifying properties were examined by following the leakage of liposome-entrapped carboxyfluorescein. KA V induced similar permeability modifications to those exhibited by known 19-residue peptaibols, while the KB I and KB II activities were weaker.

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页码：249 / 255

页数：7

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