STRUCTURAL ELUCIDATION OF TRIKONINGIN-KA AND TRIKONINGIN-KB, PEPTAIBOLS FROM TRICHODERMA-KONINGII

被引:37
作者
AUVINGUETTE, C
REBUFFAT, S
VUIDEPOT, I
MASSIAS, M
BODO, B
机构
[1] Laboratoire de Chimie, URA 401 CNRS, Muséum National d'Histoire Naturelle, 75231 Paris Cedex 05
来源
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1993年 / 02期
关键词
D O I
10.1039/p19930000249
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A Trichoderma koningii strain collected in Uruguay produced two antibiotic membrane-active peptidic groups, the trikoningins KA and KB, from which the main components KA V, KB I and KB II were purified. The peptide sequences were elucidated by FAB mass spectrometry and high-field NMR experiments. KA V was a nonadecapeptaibol, whereas KB I and KB II were two 11-residue lipopeptaibols. They all displayed antibiotic activity against Staphylococcus aureus. Their membrane-modifying properties were examined by following the leakage of liposome-entrapped carboxyfluorescein. KA V induced similar permeability modifications to those exhibited by known 19-residue peptaibols, while the KB I and KB II activities were weaker.
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页码:249 / 255
页数:7
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