DETECTION OF CAPSULAR POLYSACCHARIDE ANTIGEN OF CRYPTOCOCCUS-NEOFORMANS IN PATIENTS WITH AIDS AND NEUROCRYPTOCOCCOSIS

被引：1
作者：
CALVO, B
FISCHMAN, O
CASTELO, A
REIS, J
DELBIANCO, R
BARBOSA, RM
ZAROR, L
机构：
[1] HOSP EMILIO RIBAS,SAO PAULO,BRAZIL
[2] HOSP SERVIDOR PUBL ESTADUAL FRANCISCO MORATO OLIVEIRA,SAO PAULO,BRAZIL
来源：
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO | 1991年 / 33卷 / 06期
关键词：
D O I：
10.1590/S0036-46651991000600009
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Capsular polysaccharide antigen (AgPC) of Cryptococcus neoformans was detected by latex agglutination technique (LA) in cerebrospinal fluid and serum of patients with AIDS during their first central nervous system manifestation of the disease. Direct mycological examination and culture were used as controls. Sensitivity was 100% by LA allowing an early specific treatment of cryptococcosis. Initial titres of AgPC in such patients can be > 1000000 and it appears that when such titres are present in the serum they are related to mortality during treatment. Surviving patients showed positivity of the direct mycological examination and AgPC of C. neoformans in cerebrospinal fluid and sera even after treatment and clinical recovery.
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页码：485 / 490
页数：6
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