TAILS OF RNA POLYMERASE-II

被引：286
|
作者：
CORDEN, JL
机构：
[1] Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1990年 / 15卷 / 10期
关键词：
D O I：
10.1016/0968-0004(90)90236-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Eukaryotic RNA polymerase II contains two distinct structural domains: a catalytic core consisting of subunits that are homologous to other multisubunit RNA polymerases, and a unique extension of the carboxy-terminus of the largest subunit comprising tandem repeats of the seven amino acid sequence YSPTSPS. This repetitive 'tail' domain is essential for polymerase function in vivo. Although the nature of this essential function is unknown, actively transcribing RNA polymerase II is known to be multiphosphorylated on this repetitive domain. © 1990.
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页码：383 / 387
页数：5
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