STATIC AND SCANNING ARRAY DETECTION IN CAPILLARY ELECTROPHORESIS MASS-SPECTROMETRY

被引：25
|
作者：
REINHOUD, NJ
SCHRODER, E
TJADEN, UR
NIESSEN, WMA
DEBRAUW, MCT
VANDERGREEF, J
机构：
[1] CTR BIOPHARMACEUT SCI, DIV ANALYT CHEM, POB 9502, 2300 RA LEIDEN, NETHERLANDS
[2] FINNIGAN MAT GMBH, W-2800 BREMEN 14, GERMANY
[3] TNO, CIVO INST, INSTRUMENTAL ANAL SECT, 3700 AJ ZEIST, NETHERLANDS
来源：
JOURNAL OF CHROMATOGRAPHY | 1990年 / 516卷 / 01期
关键词：
D O I：
10.1016/S0021-9673(01)90212-2
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
An array detection system based on position- and time-resolved ion counting was evaluated for capillary electrophoresis-mass spectrometry using continuous-flow fast atom bombardment and a liquid-junction coupling. Peptides with molecular masses up to 3200 were measured. A 100-1000-fold improvement over conventional detection was demonstrated by applying the array detector in scanning and static modes. Absolute detection limits in the range 1-5 fmol are achievable. © 1990.
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页码：147 / 155
页数：9
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