NUCLEOTIDE-SEQUENCE OF CLONED CDNA FOR BOVINE CORTICOTROPIN-BETA-LIPOTROPIN PRECURSOR

被引：1681
作者：
NAKANISHI, S
INOUE, A
KITA, T
NAKAMURA, M
CHANG, ACY
COHEN, SN
NUMA, S
机构：
[1] STANFORD UNIV,MED CTR,SCH MED,SCH MED,DEPT GENET,STANFORD,CA 94305
[2] STANFORD UNIV,MED CTR,SCH MED,SCH MED,DEPT MED,STANFORD,CA 94305
来源：
NATURE | 1979年 / 278卷 / 5703期
关键词：
D O I：
10.1038/278423a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The nucleotide sequence of a 1,091-base pair cloned cDNA insert encoding bovine corticotropin-β-lipotropin precursor mRNA is reported. The corresponding amino acid sequence indicates that the precursor protein consists of repetitive units and includes a third melanotropin sequence in its cryptic portion. Pairs of lysine and arginine residues separate the component peptides of the precursor. © 1979 Nature Publishing Group.
引用
收藏
页码：423 / 427
页数：5
相关论文
共 54 条
[11]  
HABENER JF, 1976, J BIOL CHEM, V251, P3893
[12]   ENZYMIC PROCESSING OF PROPARATHYROID HORMONE BY CELL-FREE-EXTRACTS OF PARATHYROID-GLANDS [J].
HABENER, JF ;
CHANG, HT ;
POTTS, JT .
BIOCHEMISTRY, 1977, 16 (17) :3910-3917
[13]   GEL ELECTROPHORETIC SEPARATION OF COMPLEMENTARY STRANDS OF BACTERIOPHAGE DNA [J].
HAYWARD, GS .
VIROLOGY, 1972, 49 (01) :342-&
[14]   PRE-PROPARATHYROID HORMONE - ANALYSIS OF RADIOACTIVE TRYPTIC PEPTIDES AND AMINO-ACID SEQUENCE [J].
KEMPER, B ;
HABENER, JF ;
ERNST, MD ;
POTTS, JT ;
RICH, A .
BIOCHEMISTRY, 1976, 15 (01) :15-19
[15]   PURIFICATION AND CHARACTERIZATION OF THE MESSENGER-RNA CODING FOR BOVINE CORTICOTROPIN-BETA-LIPOTROPIN PRECURSOR [J].
KITA, T ;
INOUE, A ;
NAKANISHI, S ;
NUMA, S .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1979, 93 (02) :213-220
[16]   COMPUTER-ANALYSIS OF NUCLEIC-ACID REGULATORY SEQUENCES [J].
KORN, LJ ;
QUEEN, CL ;
WEGMAN, MN .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (10) :4401-4405
[17]   PRESENCE OF CORTICOTROPIN IN BRAIN OF NORMAL AND HYPOPHYSECTOMIZED RATS [J].
KRIEGER, DT ;
LIOTTA, A ;
BROWNSTEIN, MJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (02) :648-652
[18]   ISOLATION AND PRIMARY STRUCTURE OF BETA-ENDORPHIN AND BETA-LIPOTROPIN FROM BOVINE PITUITARY-GLANDS [J].
LI, CH ;
TAN, L ;
CHUNG, D .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1977, 77 (03) :1088-1093
[19]   ISOLATION AND STRUCTURE OF AN UNTRIAKONTAPEPTIDE WITH OPIATE ACTIVITY FROM CAMEL PITUITARY-GLANDS [J].
LI, CH ;
CHUNG, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (04) :1145-1148
[20]   ISOLATION, PRIMARY STRUCTURE, AND SYNTHESIS OF ALPHA-ENDORPHIN AND GAMMA-ENDORPHIN, 2 PEPTIDES OF HYPOTHALAMIC-HYPOPHYSIAL ORIGIN WITH MORPHINOMIMETIC ACTIVITY [J].
LING, N ;
BURGUS, R ;
GUILLEMIN, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (11) :3942-3946
123456