SYNTHESIS OF SUPPORT-BOUND PEPTIDES CARRYING COLOR LABELS

In order to check the possibility of labeling sub-libraries, we synthesized a colored support by acylation of aminomethyl resin with a special Boc-amino acid (a red azo dye). Syntheses of model peptides proved that the colored resin is suitable for solid phase peptide synthesis. Color labeling was also made by coupling resin-bound peptides at their N-termini with a blue dye. Colored resins as well as labeling at the N-terminus offer a possibility to simplify the preparation of support-bound peptide sub-library kits and their use in sequence determination of bioactive peptides. (C) 1994 Wiley-Liss, Inc.