INVOLVEMENT OF THE BRAIN-TYPE OF RYANODINE RECEPTOR IN T-CELL PROLIFERATION

被引：71

作者：

HAKAMATA, Y ^{[1
]}

NISHIMURA, S ^{[1
]}

NAKAI, J ^{[1
]}

NAKASHIMA, Y ^{[1
]}

KITA, T ^{[1
]}

IMOTO, K ^{[1
]}

机构：

[1] KYOTO UNIV,FAC MED,DEPT MED CHEM,SAKYO KU,KYOTO 60601,JAPAN

来源：

FEBS LETTERS | 1994年 / 352卷 / 02期

关键词：

RYANODINE RECEPTOR; CDNA CLONING; CALCIUM RELEASE; CELL PROLIFERATION; FK506; JURKAT T-LYMPHOCYTE;

D O I：

10.1016/0014-5793(94)00955-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cloning and sequence analysis of cDNA showed that the brain type of ryanodine receptor (RYR) is expressed in human Jurkat T-lymphocyte cells. Fura-2 measurements revealed that the RYR in T-cells functions as a ryanodine-sensitive, caffeine-insensitive Ca2+ release channel. Furthermore, ryanodine stimulated proliferation and altered the growth pattern of cultured human T-cells when added together with FK506.

引用

页码：206 / 210

页数：5

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