COMBINATION-DRUG THERAPY WITH CALCIUM-CHANNEL BLOCKERS IN THE TREATMENT OF SYSTEMIC HYPERTENSION

被引：19
作者：
FRISHMAN, WH
LANDAU, A
CRETKOVIC, A
机构：
[1] MONTEFIORE MED CTR,ALBERT EINSTEIN COLL MED,DEPT MED,BRONX,NY 10467
[2] ST BARNABAS HOSP CTR,BRONX,NY
来源：
JOURNAL OF CLINICAL PHARMACOLOGY | 1993年 / 33卷 / 08期
关键词：
D O I：
10.1002/j.1552-4604.1993.tb05619.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Calcium-channel blockers have been shown to be both safe and effective for treatment of patients with systemic hypertension. These drugs reduce peripheral vascular resistance predominantly by the inhibition of transmembrane calcium ion fluxes in vascular smooth muscle, and by this mechanism can reduce elevated blood pressure. To maximize blood pressure lowering efficacy in patients, calcium-channel blockers have also been used in combination with other antihypertensive treatments that have included diuretics, 6-adrenergic blockers, and angiotensin-converting enzyme inhibitors.
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页码：752 / 755
页数：4
相关论文
共 30 条
[1]   NIFEDIPINE AND BETA-BLOCKER DRUGS [J].
ANASTASSIADES, CJ .
BRITISH MEDICAL JOURNAL, 1980, 281 (6250) :1251-1252
[2]   ANTIHYPERTENSIVE TREATMENT USING CALCIUM-ANTAGONISTS IN COMBINATION WITH CAPTOPRIL RATHER THAN DIURETICS [J].
BROUWER, RML ;
BOLLI, P ;
ERNE, P ;
CONEN, D ;
KIOWSKI, W ;
BUHLER, FR .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1985, 7 :S88-S91
[3]   REVIEW OF THE CARDIOVASCULAR ADVERSITY OF THE CALCIUM-ANTAGONIST BETA-BLOCKER COMBINATION - IMPLICATIONS FOR ANTIHYPERTENSIVE THERAPY [J].
BROUWER, RML ;
FOLLATH, F ;
BUHLER, FR .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1985, 7 :S38-S44
[4]  
BUHLER FR, 1988, DRUGS, V35, P495
[5]   AN ASSESSMENT OF DILTIAZEM AND HYDROCHLOROTHIAZIDE IN HYPERTENSION - APPLICATION OF FACTORIAL TRIAL DESIGN TO A MULTICENTER CLINICAL-TRIAL OF COMBINATION THERAPY [J].
BURRIS, JF ;
WEIR, MR ;
OPARIL, S ;
WEBER, M ;
CADY, WJ ;
STEWART, WH .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1990, 263 (11) :1507-1512
[6]   CALCIUM-ANTAGONISTS COMBINED WITH BETA-BLOCKERS OR ACE INHIBITORS IN THE TREATMENT OF HYPERTENSION [J].
DAHLOF, B ;
EGGERTSEN, R ;
HANSSON, L .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1988, 12 :S104-S108
[7]  
DONNELLY R, 1989, BR J CLIN PHARM, V22, pS283
[8]  
EKELUND LG, 1982, ACTA MED SCAND, V212, P71
[9]  
FERME I, 1990, J CARDIOVASC PHARM, V16, pS46
[10]  
Frishman W H, 1987, Am J Med, V83, P15, DOI 10.1016/0002-9343(87)90631-0
123