DETERMINATION OF COLLISION-INDUCED DISSOCIATION MECHANISMS AND CROSS-SECTIONS IN ORGANOPHOSPHORUS COMPOUNDS BY ATMOSPHERIC-PRESSURE IONIZATION TANDEM MASS-SPECTROMETRY

被引：27
作者：
HARDEN, CS [1 ]
SNYDER, AP [1 ]
EICEMAN, GA [1 ]
机构：
[1] NEW MEXICO STATE UNIV,DEPT CHEM,LAS CRUCES,NM 88003
来源：
ORGANIC MASS SPECTROMETRY | 1993年 / 28卷 / 05期
关键词：
D O I：
10.1002/oms.1210280520
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Nineteen organophosphorus compounds (OPCs) of the generic classes (dialkyl alkyl'-phosphonates (twelve compounds) and tri-alkyl phosphates (seven compounds) were investigated by atmospheric pressure ionization (API) tandem mass spectrometry (MS/MS). All OPCs showed consistent and comparable collision-induced dissociation (CID) pathways allowing for a generalized scheme for dissociation. When the alkyl groups are equal to or larger than ethyl, CID mechanisms are dominated by McLafferty rearrangements and neutral losses are stable molecules in all cases except cleavage of P-C or O-C bonds to form alkyl fragment ions. CID cross-sections for the OPCs were determined with excellent reproducibility and a good correlation was found with a simple model. Inferences with respect to ionic structures were made from observed trends in the cross-section measurements. Limitations in API-MS/MS instruments of this design are found in the energy distribution of the ionization and ion sampling events.
引用
收藏
页码：585 / 592
页数：8
相关论文
共 25 条
[1]  
AUDIER HE, 1977, NOUV J CHIM, V1, P269
[2]   AN ELECTRON IMPACT INVESTIGATION OF SOME ALKYLPHOSPHATE ESTERS [J].
BAFUS, DA ;
GALLEGOS, EJ ;
KISER, RW .
JOURNAL OF PHYSICAL CHEMISTRY, 1966, 70 (08) :2614-+
[3]   MEASUREMENT OF ONSET POTENTIALS FOR PROTON-TRANSFER REACTIONS WITH A TRIPLE QUADRUPOLE INSTRUMENT [J].
BURSEY, MM ;
BLACKBURN, TR ;
MEYERHOFFER, WJ ;
MATTSON, WA .
ORGANIC MASS SPECTROMETRY, 1990, 25 (04) :232-236
[4]   THE USE OF TRIPLE QUADRUPOLES FOR SEQUENTIAL MASS-SPECTROMETRY .1. THE INSTRUMENT PARAMETERS [J].
DAWSON, PH ;
FRENCH, JB ;
BUCKLEY, JA ;
DOUGLAS, DJ ;
SIMMONS, D .
ORGANIC MASS SPECTROMETRY, 1982, 17 (05) :205-211
[5]   THE USE OF TRIPLE QUADRUPOLES FOR SEQUENTIAL MASS-SPECTROMETRY .2. A DETAILED CASE-STUDY [J].
DAWSON, PH ;
FRENCH, JB ;
BUCKLEY, JA ;
DOUGLAS, DJ ;
SIMMONS, D .
ORGANIC MASS SPECTROMETRY, 1982, 17 (05) :212-219
[6]   FRAGMENTATION OF BUTYL ACETATE ISOMERS IN THE DRIFT REGION OF AN ION MOBILITY SPECTROMETER [J].
EICEMAN, GA ;
SHOFF, DB ;
HARDEN, CS ;
SNYDER, AP .
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY AND ION PROCESSES, 1988, 85 (03) :265-275
[7]  
GRANOTH I, 1976, TOPICS PHOSPHORUS CH, V8, P41
[8]   MASS-SPECTRA OF PHOSPHONYL COMPOUNDS .3. DIMETHYL AND DIETHYL ALKANEPHOSPHONATES AND SUBSTITUTED-METHANE PHOSPHONATES [J].
GRIFFITHS, WR ;
TEBBY, JC .
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 1978, 5 (01) :101-106
[9]   STRUCTURE AND FRAGMENTATION OF DIMETHYL METHYLPHOSPHONATE AND TRIMETHYL PHOSPHITE [J].
HOLTZCLAW, JR ;
WYATT, JR ;
CAMPANA, JE .
ORGANIC MASS SPECTROMETRY, 1985, 20 (02) :90-97
[10]   TANDEM MASS-SPECTROMETRY OF ORGANOPHOSHPATE AND CARBAMATE PESTICIDES [J].
HUMMEL, SV ;
YOST, RA .
ORGANIC MASS SPECTROMETRY, 1986, 21 (12) :785-791
123