LIPOPOLYSACCHARIDE-INDUCED PRODUCTION OF TUMOR-NECROSIS-FACTOR ACTIVITY IN RATS WITH AND WITHOUT RISK-FACTORS FOR STROKE

被引：54
|
作者：
HALLENBECK, JM
DUTKA, AJ
VOGEL, SN
HELDMAN, E
DORON, DA
FEUERSTEIN, G
机构：
[1] UNIFORMED SERV UNIV HLTH SCI,F EDWARD HEBERT SCH MED,DEPT MICROBIOL,BETHESDA,MD 20814
[2] SKF IND INC,DEPT PHARMACOL,KING OF PRUSSIA,PA 19406
来源：
BRAIN RESEARCH | 1991年 / 541卷 / 01期
关键词：
TUMOR NECROSIS FACTOR-ALPHA; RAT; CEREBROSPINAL FLUID; MONOCYTE; MACROPHAGE; STROKE-RISK FACTOR; STROKE;
D O I：
10.1016/0006-8993(91)91083-D
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Rats produced more TNF activity in cerebrospinal fluid (CSF) than in blood after intracerebroventricular (i.c.v.) injection of lipopolysaccharide (LPS). After intravenous (i.v.) LPS, blood TNF levels exceeded CSF levels. Thus, brain cells appear to produce TNF in response to LPS. Rats with the stroke-risk factors hypertension or combined hypertension and genetic stroke-proneness produce more TNF in response to a provocative dose of LPS i.v. than control animals free of these risk factors. The possible relevance to stroke vulnerability is discussed.
引用
收藏
页码：115 / 120
页数：6
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