DETERMINATION OF SULFAMETHOXAZOLE AND TRIMETHOPRIM BY RATIO SPECTRA DERIVATIVE SPECTROPHOTOMETRY

被引：32
|
作者：
NEVADO, JJB
GALLEGO, JML
PENALVO, GC
机构：
[1] Department of Analytical Chemistry and Foods Technology, University of Castilla-La Mancha, Ciudad Real
来源：
FRESENIUS JOURNAL OF ANALYTICAL CHEMISTRY | 1992年 / 342卷 / 09期
关键词：
D O I：
10.1007/BF00321864
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A new method is described for analysing the binary mixture of sulfamethoxazole and trimethoprim, using the ratio spectra derivative spectrophotometry. The procedure does not require any separation step. Calibration graphs were linear up to 25 mg/l of sulfamethoxazole and up to 50 mg/l of trimethoprim; their 1:5 and 5:1 (m/m) mixtures can be resolved with recoveries between 97 and 104%. The method was satisfactorily applied for determining sulfamethoxazole and trimethoprim in different pharmaceutical products.
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页码：723 / 728
页数：6
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