CROSS-LINKING THE LEU-8 LYMPH-NODE HOMING RECEPTOR ON B-CELLS INHIBITS IMMUNOGLOBULIN-SYNTHESIS

被引：1

作者：

MURAKAWA, Y

STROBER, W

JAMES, SP

机构：

[1] Mucosal Immunity Section Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, 20892, MD

来源：

IMMUNOLOGIC RESEARCH | 1991年 / 10卷 / 3-4期

关键词：

D O I：

10.1007/BF02919739

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

About one half of circulating human B cells express the Leu-8 peripheral lymph node homing receptor that has been implicated in adhesion of lymphocytes and neutrophils to vascular endothelium. A novel and unique function of the Leu-8 antigen has been found in the present study: anti-Leu-8 monoclonal antibody directly inhibits B cell antibody production induced by SAC + IL-2, without affecting B cell proliferation or other early steps of B cell activation. This effect of anti-Leu-8 is unique in that other antibodies that inhibit B cell differentiation are not selective and also inhibit B cell proliferation. The inhibitory effect is not reversed by addition of T cells, monocytes, or recombinant IL-1 or IL-6 and is not blocked by anti-TGF-beta. Thus, the natural ligand(s) for Leu-8 may be capable of transducing regulatory signals that have a selective effect on B cell differentiation.

引用

页码：441 / 446

页数：6

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