THE 1ST PHASE INSULIN-RESPONSE TO INTRAVENOUS GLUCOSE IS HIGHLY REPRODUCIBLE

被引:39
|
作者
RAYMAN, G
CLARK, P
SCHNEIDER, AE
HALES, CN
机构
[1] Department of Clinical Biochemistry, Addenbrooke's Hospital, Cambridge
关键词
Acute phase insulin response; first phase insulin response; intravenous glucose tolerance test; reproducibility;
D O I
10.1007/BF00400209
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
To determine the reproducibility of the first phase insulin response to intravenous glucose, ten normal subjects underwent two intravenous glucose tolerance tests separated by at least two weeks. Intravenous dextrose (0.3 g/kg) was administered over 2 min by continuous infusion and arterialised-venous samples were taken from a retrogradely cannulated hand vein in the opposite arm. Within subjects, median coefficient of variation for the 3 min insulin was 4.0% (range 1.2-24.3%) and median coefficient of variation for the 0-10 min area was 6.7% (range 1.7-18.8%). These coefficients of variation are close to those of the assay itself (< 10%). Despite this, between subject responses varied by greater than sixfold. In conclusion, contrary to previous reports the intravenous glucose tolerance test is highly reproducible. This makes it a very valuable tool for further studies of the pathogenesis of diabetes. © 1990 Springer-Verlag.
引用
收藏
页码:631 / 634
页数:4
相关论文
共 50 条
  • [11] INSULIN-RESPONSE TO GLUCOSE LOADING AFTER INTRAVENOUS CIMETIDINE
    SCARPIGNATO, C
    TIRELLI, F
    STARCICH, R
    BERTACCINI, G
    DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH, 1981, 7 (02) : 135 - 138
  • [12] EARLY PHASE INSULIN-RESPONSE TO INTRAVENOUS GLUCOSE IN PATIENTS WITH ESSENTIAL-HYPERTENSION
    KENDERESKI, A
    MICIC, D
    SUMARAC, M
    MACUT, DJ
    ZORIC, S
    COLIC, M
    DIABETOLOGIA, 1995, 38 : A112 - A112
  • [13] ESTIMATION OF EARLY INSULIN-RESPONSE TO INTRAVENOUS GLUCOSE INJECTION
    THORELL, JI
    NOSSLIN, B
    STERKY, G
    JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 1973, 82 (01): : 101 - 110
  • [14] INSULIN-RESPONSE TO INTRAVENOUS GLUCOSE INJECTION IN A FAMILY WITH A GLUCOKINASE MUTATION
    SHIMADA, F
    KANATSUKA, A
    SAKURADA, M
    HASHIMOTO, N
    SANO, H
    HATANAKA, Y
    MIKI, T
    MAKINO, H
    YOSHIDA, S
    HORMONE AND METABOLIC RESEARCH, 1994, 26 (08) : 392 - 394
  • [15] INSULIN-RESPONSE OF MERINO SHEEP TO AN INTRAVENOUS GLUCOSE-LOAD
    PROCOS, J
    VANDERWALT, JG
    LABUSCHAGNE, FJ
    SOUTH AFRICAN MEDICAL JOURNAL, 1976, 50 (26): : 1003 - 1003
  • [16] EARLY INSULIN-RESPONSE TO INTRAVENOUS GLUCOSE IN HOSPITALIZED-PATIENTS
    FORD, S
    DIABETES, 1977, 26 : 396 - 396
  • [17] EFFECT ON 1ST PHASE INSULIN-SECRETION TO INTRAVENOUS GLUCOSE OF DIABETICS AND THEIR ACETYLATOR STATUS
    BURROWS, AW
    HOCKADAY, TDR
    MANN, JI
    CLINICAL SCIENCE AND MOLECULAR MEDICINE, 1978, 54 (02): : P22 - P22
  • [18] INSULIN-RESPONSE TO INTRAVENOUS ALIMENTATION
    GENUTH, S
    NEW ENGLAND JOURNAL OF MEDICINE, 1973, 289 (02): : 107 - 107
  • [20] EARLY INSULIN-RESPONSE TO AN INTRAVENOUS GLUCOSE-TOLERANCE TEST IN HORSES
    GIRAUDET, A
    HINCHCLIFF, KW
    KOHN, CW
    MCKEEVER, KH
    AMERICAN JOURNAL OF VETERINARY RESEARCH, 1994, 55 (03) : 379 - 381