DIFFUSIVE CHARACTERISTICS OF TESTOSTERONE IN NOVEL GELS .2. INTERPRETATION FOR DIFFERENT CONCENTRATIONS OF TESTOSTERONE

被引：1

作者：

FALSONREIG, F ^{[1
]}

CONRATH, G ^{[1
]}

BESNARD, M ^{[1
]}

LECLERC, B ^{[1
]}

COUARRAZE, G ^{[1
]}

机构：

[1] UNIV PARIS SUD,CNRS,URA 1218,PHYS PHARMACEUT LAB,F-92296 CHATENAY MALABRY,FRANCE

来源：

JOURNAL OF CONTROLLED RELEASE | 1990年 / 14卷 / 02期

关键词：

concentration profile; diffusion coefficient; release kinetics; silicic acid gel; testosterone;

D O I：

10.1016/0168-3659(90)90153-K

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The diffusion of testosterone was analyzed in a gel consisting of propylene glycol dipelargonate and silicic acid, in contact with a microporous polytetrafluoroethylene membrane. The release kinetics and the concentration profiles in the gel were determined for different concentrations of testosterone above and below the solubility concentration. The existence of a non-sink boundary layer has led to an adaptation of the classical theoretical models of interpretation. © 1990.

引用

页码：169 / 177

页数：9

共 14 条

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