METHYLATION OF DNA IN MEGALOBLASTIC-ANEMIA

被引：9

作者：

PERRY, J ^{[1
]}

CHANARIN, I ^{[1
]}

DEACON, R ^{[1
]}

LUMB, M ^{[1
]}

机构：

[1] MRC,CLIN RES CTR,BIOCHEM SCI SECT,WATFORD RD,HARROW HA1 3UJ,MIDDX,ENGLAND

来源：

JOURNAL OF CLINICAL PATHOLOGY | 1990年 / 43卷 / 03期

关键词：

D O I：

10.1136/jcp.43.3.211

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Methylation of cytosine residues in DNA samples, collected before and serially after cobalamin treatment from patients with cobalamin deficiency was studied using restriction endonucleases Hpa II and Msp I and an ε globin gene probe. There was no evidence of hypomethylation in any of the samples. It was concluded that although hypomethylation of metabolites such as choline occurs, that of DNA is preserved in megaloblastic anaemia.

引用

页码：211 / 212

页数：2

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