RELATIONSHIP BETWEEN CARCINOGENICITY IN RODENTS AND THE INDUCTION OF SISTER CHROMATID EXCHANGES AND CHROMOSOMAL-ABERRATIONS IN CHINESE-HAMSTER OVARY CELLS

被引：34

作者：

ROSENKRANZ, HS ^{[1
]}

ENNEVER, FK ^{[1
]}

KLOPMAN, G ^{[1
]}

机构：

[1] CASE WESTERN RESERVE UNIV,DEPT CHEM,CLEVELAND,OH 44106

来源：

MUTAGENESIS | 1990年 / 5卷 / 06期

关键词：

D O I：

10.1093/mutage/5.6.559

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Two independent analyses were carried out to compare the induction of sister chromatid exchanges and of chromosomal aberrations as predictors of carcinogenicity. Using both a classical and a Bayesian approach, as well as by analysis of the structural fragments generated by CASE, an artificial intelligence system, it is included that individually neither of these tests is a satisfactory predictor of carcinogenicity. However, because the analysis revealed that each of the cytogenetic assays responds to a different set of structural features associated with carcinogenicity, it can be concluded that the assays can be included in a battery of tests to improve predictivity. © 1990 Oxford University Press.

引用

页码：559 / 571

页数：13

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