COMPARISON OF THE INDUCTION BY CIGARETTE-SMOKE CONDENSATES OF SISTER-CHROMATID EXCHANGES IN CHINESE-HAMSTER CELLS AND OF MUTATIONS IN SALMONELLA-TYPHIMURIUM

被引：36
作者：
DERAAT, WK
机构：
[1] Division of Technology for Society TNO, Delft
来源：
MUTATION RESEARCH | 1979年 / 66卷 / 03期
关键词：
D O I：
10.1016/0165-1218(79)90086-7
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Three cigarette smoke condensates were tested for the induction of sister-chromatid exchanges in ovary cells of the Chinese hamster and for mutations in Salmonella typhimurium. In the sister-chromatid exchange test an effect was obtained that was not enhanced by the inclusion of a system for metabolic activation. In the Salmonella test, an effect was only obtained by including rat-liver homogenates derived from rats treated with inducers of the enzyme systems necessary for metabolic activation. It appears that the SCE test and the Salmonella test are sensitive to different components of cigarette smoke condensates. © 1979.
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页码：253 / 259
页数：7
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