ANTIEPILEPTIC DRUGS - METABOLISM IN PREGNANCY

被引：124

作者：

DAM, M

CHRISTIANSEN, J

MUNCK, O

MYGIND, KI

机构：

[1] Hvidovre Hospital, University Clinic of Neurology, Hvidovre

来源：

CLINICAL PHARMACOKINETICS | 1979年 / 4卷 / 01期

关键词：

D O I：

10.2165/00003088-197904010-00005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In an open prospective clinical study, plasma clearance of phenytoin, phenobarbitone and carbamazepine was assessed in 14 epileptic patients during and after pregnancy. Plasma clearance showed a marked increase during pregnancy, reached a maximum just before or after delivery, and then decreased to early pregnancy values. The relative plasma concentration of carbamazepine-10,11-epoxide to that of carbamazepine increased similarly during pregnancy. The protein binding of carbamazepine and the epoxide was not influenced by pregnancy. A higher rate of hepatic drug metabolism, due to alteration of the physiological state in pregnancy is suggested as the most reasonable explanation. No change in seizure frequency was seen, probably because of frequent dose adjustments in order to keep plasma levels within the optimum range. © 1979, ADIS Press Australasia Pty Ltd.. All rights reserved.

引用

页码：53 / 62

页数：10

共 24 条

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