OBESITY AND COLORECTAL ADENOMATOUS POLYPS

被引：91

作者：

NEUGUT, AI

LEE, WC

GARBOWSKI, GC

WAYE, JD

FORDE, KA

TREAT, MR

FENOGLIOPREISER, C

机构：

[1] VET ADM MED CTR,DEPT PATHOL,ALBUQUERQUE,NM 87108

[2] COLUMBIA UNIV COLL PHYS & SURG,DEPT SURG,NEW YORK,NY 10032

[3] CUNY MT SINAI SCH MED,NEW YORK,NY 10029

[4] COLUMBIA UNIV COLL PHYS & SURG,SCH PUBL HLTH,NEW YORK,NY 10032

来源：

JOURNAL OF THE NATIONAL CANCER INSTITUTE | 1991年 / 83卷 / 05期

关键词：

D O I：

10.1093/jnci/83.5.359

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Obesity has been investigated as a risk factor for various malignancies, including colon cancer. A case-control study was conducted on patients in three colonoscopy practices in New York City to determine possible risk factors for colorectal adenomatous polyps, a known precursor lesion for most cases of colorectal cancer. Among 301 case subjects with incident adenomatous polyps (174 men and 127 women) and 506 control subjects (223 men and 283 women), an increased risk was observed with increasing body mass index in women (odds ratio 2.1, 95% confidence interval 1.1-4.0; for highest versus lowest quartile, linear trend P = .02). A nonsignificant trend was observed for men. The increased risk seen in women is consistent with prior observations regarding reproductive hormonal and dietary risk factors for colorectal cancer.

引用

页码：359 / 361

页数：3

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