LYSERGIC ACID DIETHYLAMIDE - ROLE IN CONVERSION OF PLASMA TRYPTOPHAN TO BRAIN SEROTONIN (5-HYDROXYTRYPTAMINE)

被引：68

作者：

LIN, RC

NGAI, SH

COSTA, E

机构：

[1] Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York

[2] Laboratory of Preclinical Pharmacology, National Institute of Mental Health, St. Elizabeths Hospital, Washington

来源：

SCIENCE | 1969年 / 166卷 / 3902期

关键词：

D O I：

10.1126/science.166.3902.237

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Injections of D-lysergic acid diethylamide decrease the turnover rate of 5-hydroxytryptamine of rat brain, as measured from the conversion of 14C-tryptophan into 14C-5-hydroxytryptamine. The 2-bromolysergic acid diethylamide given in doses fivefold greater than those of lysergic acid diethylamide fails to change the rate of 14C-tryptophan conversion into 14C-5-hydroxytryptamine. The effect of D-lysergic acid diethylamide is discussed with regard to its action on brain serotonergic neurons and its psychotomimetic effects.

引用

页码：237 / &

共 16 条

[1] LYSERGIC ACID DIETHYLAMIDE - SENSITIVE NEURONAL UNITS IN MIDBRAIN RAPHE
AGHAJANIAN, GK
FOOTE, WE
SHEARD, MH
[J]. SCIENCE, 1968, 161 (3842) : 706 - +
[2] ANDEN NE, 1968, BRIT J PHARMACOL, V34, P1
[3] BOGDANSKI DF, 1956, J PHARMACOL EXP THER, V117, P82
[4] A SIMPLE EFFICIENT LIQUID SCINTILLATOR FOR COUNTING AQUEOUS SOLUTIONS IN A LIQUID SCINTILLATION COUNTER
BRAY, GA
[J]. ANALYTICAL BIOCHEMISTRY, 1960, 1 (4-5) : 279 - 285
[5] COSTA E, 1956, P SOC EXP BIOL MED, V91, P39
[6] DENCKLA WD, 1967, J LAB CLIN MED, V69, P160
[7] Diaz P M, 1968, Adv Pharmacol, V6, P75
[8] KAWAI N, IN PRESS
[9] Keglevic D, 1968, Adv Pharmacol, V6, P79
[10] LIN RC, IN PRESS

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