USE OF SITE-DIRECTED MUTAGENESIS TO INVESTIGATE THE BASIS FOR THE SPECIFICITY OF HIRUDIN

被引：175
作者：
BRAUN, PJ [1 ]
DENNIS, S [1 ]
HOFSTEENGE, J [1 ]
STONE, SR [1 ]
机构：
[1] FRIEDRICH MIESCHER INST,POB 2543,CH-4002 BASEL,SWITZERLAND
来源：
BIOCHEMISTRY | 1988年 / 27卷 / 17期
关键词：
D O I：
10.1021/bi00417a048
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：6517 / 6522
页数：6
相关论文
共 46 条
[1]  
BAGDY O, 1976, METHOD ENZYMOL, V45, P669
[2]   THE CYSTATINS - A NEW CLASS OF PEPTIDASE INHIBITORS [J].
BARRETT, AJ .
TRENDS IN BIOCHEMICAL SCIENCES, 1987, 12 (05) :193-196
[3]   PHYSICAL EVIDENCE FOR AN APOLAR BINDING-SITE NEAR CATALYTIC CENTER OF HUMAN ALPHA-THROMBIN [J].
BERLINER, LJ ;
SHEN, YYL .
BIOCHEMISTRY, 1977, 16 (21) :4622-4626
[4]  
BLOMBACK JG, 1977, CHEM BIOL THROMBIN, P275
[5]   ALPHA-1-ANTITRYPSIN AND THE SERPINS - VARIATION AND COUNTERVARIATION [J].
CARRELL, R ;
TRAVIS, J .
TRENDS IN BIOCHEMICAL SCIENCES, 1985, 10 (01) :20-24
[6]   THE FUNCTIONAL DOMAIN OF HIRUDIN, A THROMBIN-SPECIFIC INHIBITOR [J].
CHANG, JY .
FEBS LETTERS, 1983, 164 (02) :307-313
[7]  
CLAESON G, 1977, NEW METHODS ANAL COA, P37
[8]   THE CONFORMATIONS OF HIRUDIN IN SOLUTION - A STUDY USING NUCLEAR-MAGNETIC-RESONANCE, DISTANCE GEOMETRY AND RESTRAINED MOLECULAR-DYNAMICS [J].
CLORE, GM ;
SUKUMARAN, DK ;
NILGES, M ;
ZARBOCK, J ;
GRONENBORN, AM .
EMBO JOURNAL, 1987, 6 (02) :529-537
[9]   ISOLATION AND CHARACTERIZATION OF HIRUDIN ISOINHIBITORS AND SEQUENCE-ANALYSIS OF HIRUDIN-PA [J].
DODT, J ;
MACHLEIDT, W ;
SEEMULLER, U ;
MASCHLER, R ;
FRITZ, H .
BIOLOGICAL CHEMISTRY HOPPE-SEYLER, 1986, 367 (08) :803-811
[10]   THE COMPLETE AMINO-ACID-SEQUENCE OF HIRUDIN, A THROMBIN SPECIFIC INHIBITOR - APPLICATION OF COLOR CARBOXYMETHYLATION [J].
DODT, J ;
MULLER, HP ;
SEEMULLER, U ;
CHANG, JY .
FEBS LETTERS, 1984, 165 (02) :180-184
12345