METAL-ION SPECIATION IN BLOOD-PLASMA AS A TOOL FOR ELUCIDATING THE IN-VIVO BEHAVIOR OF RADIOPHARMACEUTICALS CONTAINING SM-153 AND HO-166

被引：37

作者：

JARVIS, NV

WAGENER, JM

JACKSON, GE

机构：

[1] ATOM ENERGY CORP S AFRICA LTD,DEPT PROC TECHNOL,PRETORIA 0001,SOUTH AFRICA

[2] UNIV CAPE TOWN,DEPT CHEM,RONDEBOSCH 7700,SOUTH AFRICA

来源：

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS | 1995年 / 09期

关键词：

D O I：

10.1039/dt9950001411

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

In order to elucidate the in vivo behaviour of Sm-III and Ho-III, complex-formation constants for a range of blood plasma metal ions as well as these with the octaanion ethylenediaminetetramethylenephosphonate (edtmp) have been measured at 37 degrees C and / = 150 mmol dm(-3). The speciation in the absence and presence of edtmp and/or transferrin was calculated by the program ECCLES and is used to explain the apparently anomalous discrepancies in the uptake of the two metals by bone in a baboon model. The computer results predicted the mobilisation of Zn-II and, when tested clinically. it was found that edtmp indeed removes this ion from blood plasma.

引用

页码：1411 / 1415

页数：5

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