Neuropathic Pain in Elderly Patients with Chronic Low Back Painand Effects of Pregabalin: A Preliminary Study

被引：15
作者：
Sakai, Yoshihito [1 ]
Ito, Kenyu [2 ]
Hida, Tetsuro [2 ]
Ito, Sadayuki [1 ]
Harada, Atsushi [1 ]
机构：
[1] Natl Ctr Geriatr & Gerontol, Dept Orthopaed Surg, 35 Gengo,Morioka Cho, Obu, Japan
[2] Nagoya Univ, Sch Med, Dept Orthopaed Surg, Nagoya, Aichi, Japan
来源：
ASIAN SPINE JOURNAL | 2015年 / 9卷 / 02期
基金：
日本学术振兴会;
关键词：
Low back pain; Elderly person; Pregabalin; Treatment outcome;
D O I：
10.4184/asj.2015.9.2.254
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
Study Design: Preliminary study. Purpose: To assess the association of neuropathic pain with chronic low back pain (LBP) and the effect of pregabalin on neuropathic pain in the elderly. Overview of Literature: Of those with chronic LBP, 37% were predominantly presenting with neuropathic pain in young adults. Pregabalin is effective for pain in patients with diabetic neuropathy and peripheral neuralgia. No study has reported on the effects of pregabalin for chronic LBP in elderly patients yet. Methods: Pregabalin was administered to 32 patients (age, >= 65 years) with chronic LBP for 4 weeks. Pain and activities of daily living were assessed using the Neuropathic Pain Screening Questionnaire (NePSQ), the pain DETECT questionnaire, visual analog scale, the Japanese Orthopedic Association score, the short form of the McGill Pain Questionnaire and the Roland Morris Disability Questionnaire. Modic change and spinal canal stenosis were investigated using magnetic resonance imaging. Results: Altogether, 43.3% of patients had neuropathic pain according to the NePSQ and 15.6% patients had pain according to the pain DETECT. The efficacy rate of pregabalin was 73.3%. A significant effect was observed in patients with neuropathic pain after 4 weeks of administration. Conclusions: Neuropathic pain was slightly less frequently associated with chronic LBP in the elderly. Pregabalin was effective in reducing pain in patients with chronic LBP accompanied with neuropathic pain. Lumbar spinal stenosis and lower limb symptoms were observed in patients with neuropathic pain. We recommend the use of pregabalin for patients after evaluating a screening score, clinical symptoms and magnetic resonance imaging studies.
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页码：254 / 262
页数：9
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