DNA-PLOIDY OF FIBROLAMELLAR HEPATOCELLULAR-CARCINOMA BY IMAGE-ANALYSIS

被引：12

作者：

ORSATTI, G

GREENBERG, PD

ROLFES, DB

ISHAK, KG

PARONETTO, F

机构：

[1] CUNY,MT SINAI MED CTR,LILLIAN & HENRY M STRATTON HANS POPPER DEPT PATHO,NEW YORK,NY

[2] HOLY CROSS HOSP,SILVER SPRING,MD

[3] ARMED FORCES INST PATHOL,DEPT HEPAT & GASTROINTESTINAL PATHOL,WASHINGTON,DC

来源：

HUMAN PATHOLOGY | 1994年 / 25卷 / 09期

关键词：

FIBROLAMELLAR CARCINOMA; HEPATOCELLULAR CARCINOMA; NUCLEAR DNA CONTENT; DNA PLOIDY;

D O I：

10.1016/0046-8177(94)90015-9

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Twelve cases of fibrolamellar hepatocellular carcinoma (FLC) were evaluated for DNA ploidy by means of image analysis of Feulgen-stained tissue sections. All of the tumors showed a nondiploid DNA distribution (six aneuploid and six tetraploid); no diploid pattern was found. The nuclear area of the tumors (53.8 mu m(2) +/- 18.0; mean +/- standard deviation) was significantly larger than that of the surrounding noncancerous livers (33.2 +/- 4.7; P < .0001). These findings suggest that DNA content in fibrolamellar carcinoma (FLC) is not directly related to the clinical behavior and that other factors may be responsible for the better prognosis of this variant of HCC. HUM PATHOL 25:936-939. This is a US government work. There are no restrictions on its use.

引用

页码：936 / 939

页数：4

共 31 条

[21]

2-X

[22] FLOW CYTOMETRIC ANALYSIS OF THE NUCLEAR-DNA CONTENT OF HEPATOCELLULAR-CARCINOMA [J].